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Tetanus Toxins & Related Products Tetanus toxin is a potent neurotoxin that is taken up by presynaptic terminals at the neuromuscular junction, travels retrogradely within motor neurons and is transported transsynaptically to spinal cord interneurons. Upon entering the motor neuron, tetanus toxin associates with lipid rafts, is incorporated into non-acidified vesicles, sorted in a Rab 5/7 dependent pathway and transported to the cell body. The tetanus toxin is trancytosed so that it enters upstream inhibitory neurons where it cleaves VAMP-2, inhibiting neurotransmitter release. Tetanus toxin inhibits neurotransmitter release with great potency and selectivity, cleaving a bond in vesicle-associated membrane protein-2 (VAMP-2) or synaptobrevin-2, thereby preventing the fusion of synaptic vesicles with the presynaptic membrane. Tetanus toxoid is currently used as a vaccine to produce immunity to tetanus, the disease caused by Clostridium tetani. Additionally, tetanus toxoid functions as a carrier of conjugated polysaccharides in the development of vaccines against encapsulated bacterial pathogens. Tetanus toxin C-fragment consists of the C-terminal portion of the heavy chain of tetanus toxin. Although it is non toxic, it retains the binding and internalization properties associated with intact tetanus toxin. These properties make C-fragment and its conjugates useful in tracing nerve fiber connections in the CNS. List Labs produces C-fragment, Product # 193, from enzyme digested Clostridium tetani toxin. Our Citations include information referencing the use of tetanus toxins in research. Our Support Portal provides technical information on our tetanus products. Visit our blog to learn more about research adjuvants including tetanus List Labs' other products, services, and research. GST Synaptobrevin-2 Protein Substrate
for C. botulinum Types B, D, and F GST Synaptobrevin-2 Protein Substrate for C. botulinum Types B, D, and F #510A Tetanolysin from Clostridium tetani Tetanolysin from Clostridium tetani Tetanus Toxin C-Fragment from Clostridium tetani Tetanus Toxin C-Fragment from Clostridium tetani #193 Tetanus Toxin C-Fragment from Clostridium tetani, FITC Conjugate Tetanus Toxin C-Fragment from Clostridium tetani, FITC Conjugate #196A Tetanus Toxin from Clostridium tetani Tetanus Toxin from Clostridium tetani #190A, #190B Tetanus Toxin Light Chain, Recombinant Tetanus Toxin Light Chain, Recombinant #650A Tetanus Toxoid from Clostridium tetani Tetanus Toxoid from Clostridium tetani #191A, #191B