RANTES is a CC chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant Rat RANTES is a 7.8 kDa protein containing 68 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines.
Source: E.coli
Synonyms: Regulation upon Activation Normal T cell Express Sequence, CCL5, SIS-delta
AA Sequence: SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Assay#1: ?Determined by its ability to chemoattract rat peritoneal macrophages using a concentration range of 50.0-100.0 ng/ml. Assay#2: ?Determined by its ability to chemoattract human blood monocytes using a concentration range of 10.0-100.0 ng/ml.
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