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Human IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family.? It binds and signals through the IL-1RL1/ST2 receptor, to activate NF-κB and MAP kinases.? IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities. Recombinant Human IL-33 is a 17.9 kDa protein containing 159 amino acid residues.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: Interleukin-33, IL-1 F11, NF-HEV

AA Sequence: SITGISPITE YLASLSTYND QSITFALEDE SYEIYVEDLK KDEKKDKVLL SYYESQHPSN ESGDGVDGKM LMVTLSPTKD FWLHANNKEH SVELHKCEKP LPDQAFFVLH NMHSNCVSFE CKTDPGVFIG VKDNHLALIK VDSSENLCTE NILFKLSET

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate the proliferation of mouse D10S cells. The expected ED₅₀ is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10⁷ units/mg.