I-TAC is a "non-ELR" CXC chemokine that is regulated by interferon and signals through the CXCR3 receptor. I-TAC is chemoattractant for IL-2-activated T cells, but does not affect freshly isolated un-stimulated T cells, neutrophils, or monocytes. Recombinant Murine I-TAC is a 9.0 kDa protein containing 79 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines.
Source: E.coli
Synonyms: Interferon Inducible T-Cell α Chemokine, CXCL11, B-R1
AA Sequence: FLMFKQGRCL CIGPGMKAVK MAEIEKASVI YPSNGCDKVE VIVTMKAHKR QRCLDPRSKQ ARLIMQAIEK KNFLRRQNM
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by its ability to chemoattract murine CXCR3-transfected HEK293 cells using a concentration range of 10.0-100.0 ng/ml.
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