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Valinomycin

品牌：AG Scientific

貨號(hào)：

規(guī)格：100 mg

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CAS:2001-95-8Formula:C54H90N6O18C54H90N6O18MW:1111.34Appearance:WhitecrystallinepowderPurity:98.47%byHPLC&99%byTLC

商品詳情參考文獻(xiàn) 相關(guān)資料

Valinomycin is an antibiotic which acts as a potassium (K+) ionophore. Induces K+ conductivity in cell membranes. Also active in vitro against Mycobacterium Tuberculosis, and as an apoptosis inducer.

Valinomycin is used diagnostically in ion selective electrodes because of its preferential ability to conduct K+ across the electrodes membrane. Valinomycin induced stimulation of mitochondrial energy dependent reversible swelling, supported by succinate oxidation, cytochrome c (cyto-c) and sulfite oxidase (Sox) (both are?present in the mitochondrial intermembrane space (MIS)) are released outside.Valinomycin also inhibits hyphal growth in other dimorphic fungi, Candida tropicalis and Aureobasidium pullulan. It affects the morphology of Candida albicans.

Additional Information

Product #	V-1013
CAS #	2001-95-8
Chemical Name	(2S,8R,11S,14S,17R,20R,23S,26S,29R,32R,35S)-2,14,26-TRIMETHYL-5,8,11,17,20,23,29,32,35-NONA(PROPAN-2-YL)-3,9,15,21,27,33-HEXAOXA-6,12,18,24,30,36-HEXAZACYCLOHEXATRIACONTANE-1,4,7,10,13,16,19,22,25,28,31,34-DODECONE
Formula	C₅₄H₉₀N₆O₁₈ C54H90N6O18
MW	1111.34
Appearance	White crystalline powder
Purity	98.47% by HPLC & 99% by TLC
Solubility	Soluble in Acetic Acid, CHCl₃, DMSO or Ether.
Melting Point	374 °C
Storage Temp	+4°C
Therapeutic Area	Pulmonary Disorders
Use	Valinomycin is potent agent against severe acute respiratory-syndrome coronavirus (SARS-CoV) in infected Vero E6 cells

Additional Information

Merck Index	Merck Index: 13.9978.2001
MDL Number	MFCD00005114
ChemACX	X1008618-5
InChI	InChI=1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34+,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1
SMILES	C[C@H]1C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O[C@H](C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O[C@H](C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C