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OICR9429,WDR5Antagonist

品牌：Xcessbio

貨號：M60255-2s

規(guī)格：2 mg solid

貨期：

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OICR9429,WDR5Antagonist

商品詳情參考文獻相關(guān)資料

Product Information

Molecular Weight:	555.59
Formula:	C₂₉H₃₂F₃N₅O₃
Purity:	≥98%
CAS#:	n/a
Solubility:	DMSO up to 50 mM
Chemical Name:	N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

OICR9429 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist (Kd ~24-52 nM). It has >100-fold selectivity over other methyltransferases tested. It disrupts WDR5 interaction with peptide regions of MLL and Histone 3. OICR-9429 also disrupts the interaction of WDR5 with MLL1 and RbBP5 in cells with IC50 values below 1 μM.

How to Use:

In vitro: OICR9429 was used at 5-10 μM final concentration in various in vitro assays.
In vivo: n/a

Reference: