Biological Activity:
EX-527 is a highly potent and selective inhibitor of SIRT1 with an IC50?~98 nM. It does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50?~20-100 μM). EX-527 has been used to investigate the relationship between SIRT1-mediated deacetylation of p53, p53 activity, and cell survival following DNA damage, as well as many other biological processes involving SIRT1.?
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How to Use:
Reference:
BIOLEAF熱搜 BIOLEAF試劑盒 BIOLEAF ELISA BIOLEAF試劑 BIOLEAF品牌 BIOLEAF抗體 BIOLEAF耗材 BIOLEAF小儀器
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