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GSK-LSD1,LSD1Inhibitor
品牌:Xcessbio
貨號:M60179-2s
規(guī)格:2mg solid
貨期:
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GSK-LSD1,LSD1Inhibitor

商品詳情 參考文獻(xiàn) 相關(guān)資料
Product Information
Molecular Weight: 289.24
Formula: C14H22Cl2N2
Purity: ≥98%
CAS#: ?1431368-48-7
Solubility: DMSO up to 100 mM
Chemical Name: N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine HCl salt
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

GSK-LSD1 is a highly potent, specific and irreversible inhibitor of Lysine Specific Demethylase-1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50?~16 nM, and is > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B).? GSK-LSD1 induces gene expression changes in cancer cell lines (average EC50 < 5 nM) and inhibits cancer cell line growth (average EC50 < 5 nM).?

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How to Use:

  • In vitro:? GSK-LSD1 was used at 1 μM in vitro.
  • In vivo:??n/a

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Reference:

  • 1. http://www.thesgc.org/chemical-probes/epigenetics

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Products are for research use only. Not for human use.

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