產(chǎn)品介紹 品名 Monoclonal Antibody to Human Factor P#1 貨號(hào) A233 規(guī)格 100 μL 同種型 IgG1k 蛋白質(zhì)濃度 > 1.0 mg/mL 純度 ≥ 95% by SDS PAGE 緩沖液 Borate Buffered Saline (pH 8.4 ± 0.2) 物種交叉反應(yīng) None 儲(chǔ)存 ≤ 30 Days 2-8?C > 30 Days ≤ –20?C 使用說(shuō)明 For Research Use Only. Not for use in Diagnostic Procedures 產(chǎn)品描述 A murine monoclonal antibody to an epitope on Factor P. This monoclonal antibody was raised against purified Factor P. It inhibits the function of Factor P. Quidel's Factor P Monoclonal Antibody #1 has been used in a variety of experimental techniques including EIA 背景 The function of Properdin (Factor P) is to stabilize the alternative pathway convertase. Its binding to C3bBb extends the half-life of the complex. The concentration in plasma is approximately 20 μg/mL. Factor P has a molecular weight of 224 kDa, consisting of four identical chains of approximately 53 kDa molecular weight. The alternative complement pathway provides innate protection against microbial agents in the absence of specific antibody. The activation of this complement pathway can be triggered by a variety of substances, including microbial polysaccharides or lipids, gram-negative bacterial lipopolysaccharides, and surface determinants present on some viruses, parasites, virally infected mammalian cells and cancer cells. In autoimmune diseases, the alternative complement pathway may contribute directly to tissue damage. 特異性 The specificity of the monoclonal antibody was established via ELISA and RIA. This antibody was shown to bind to highly purified Factor P, but not to C3, Factor B, Factor H, nor other isolated complement proteins. The antibody was also shown to immunoprecipitated radiolabeled Factor P, using protein A-bearing bacteria to capture the immune complex. The antibody was shown to inhibit the binding of radiolabeled Factor P to EC3b cells. 應(yīng)用 參考資料 1、Shiraishi, M. et al. Improved hepatic microcirculation by human soluble urinary thrombomodulin in the xeno-perfused porcine liver. Transplantation 731:1046-1050 (2001). 2、Harboe, M. et al. The role of properdin in zymosan- and Escherichia coli-induced complement activation. J Immunol 189(5):2606- 2613 (2012)
產(chǎn)品介紹
Monoclonal Antibody to Human Factor P#1
A233
100 μL
IgG1k
> 1.0 mg/mL
≥ 95% by SDS PAGE
Borate Buffered Saline (pH 8.4 ± 0.2)
None
≤ 30 Days 2-8?C
> 30 Days ≤ –20?C
For Research Use Only. Not for use in Diagnostic Procedures
A murine monoclonal antibody to an epitope on Factor P.
This monoclonal antibody was raised against purified Factor P. It inhibits the function of Factor P.
Quidel's Factor P Monoclonal Antibody #1 has been used in a variety of experimental techniques including EIA
The function of Properdin (Factor P) is to stabilize the alternative pathway convertase. Its binding to C3bBb extends the half-life of the complex. The concentration in plasma is approximately 20 μg/mL. Factor P has a molecular weight of 224 kDa, consisting of four identical chains of approximately 53 kDa molecular weight.
The alternative complement pathway provides innate protection against microbial agents in the absence of specific antibody. The activation of this complement pathway can be triggered by a variety of substances, including microbial polysaccharides or lipids, gram-negative bacterial lipopolysaccharides, and surface determinants present on some viruses, parasites, virally infected mammalian cells and cancer cells. In autoimmune diseases, the alternative complement pathway may contribute directly to tissue damage.
The specificity of the monoclonal antibody was established via ELISA and RIA. This antibody was shown to bind to highly purified Factor P, but not to C3, Factor B, Factor H, nor other isolated complement proteins. The antibody was also shown to immunoprecipitated radiolabeled Factor P, using protein A-bearing bacteria to capture the immune complex. The antibody was shown to inhibit the binding of radiolabeled Factor P to EC3b cells.
1、Shiraishi, M. et al. Improved hepatic microcirculation by human soluble urinary thrombomodulin in the xeno-perfused porcine liver. Transplantation 731:1046-1050 (2001).
2、Harboe, M. et al. The role of properdin in zymosan- and Escherichia coli-induced complement activation. J Immunol 189(5):2606- 2613 (2012)
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